Phentolamine Methanesulfonate
Phentolamine Methanesulfonate - General Information
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease. [PubChem]
Pharmacology of Phentolamine Methanesulfonate
Phentolamine Methanesulfonate is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine Methanesulfonate is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine Methanesulfonate works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine Methanesulfonate, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Phentolamine Methanesulfonate for patients
Phentolamine Methanesulfonate Interactions
Diagnosis of pheochromocytoma - phentolamine blocking test.
The test is most reliable in detecting pheochromocytoma in patients with sustained hypertension and least reliable in those with paroxysmal hypertension. False-positive tests may occur in patients with hypertension without pheochromocytoma.
Phentolamine Methanesulfonate Contraindications
Myocardial infarction, history of myocardial infarction, coronary insufficiency, angina, or other evidence suggestive of coronary artery disease; hypersensitivity to phentolamine or related compounds.
Additional information about Phentolamine Methanesulfonate
Phentolamine Methanesulfonate Indication: For the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Also for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision.
Mechanism Of Action: Phentolamine Methanesulfonate produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Phentolamine
Synonyms: Not Available
Drug Category: Antihypertensive Agents; Sympatholytics
Drug Type: Small Molecule; Approved
Other Brand Names containing Phentolamine: Phenotolamine; Phentalamine; Phentolamine Mesilate; Phentolamine Mesylate; Phentolamine Mesylate [USAN]; Phentolamine Methanesulfonate; Phentolamine Methanesulphonate; Phentolamine, Methyl Sulfonate; Regitin; Regitin Methanesulphonate; Regitine; Regitine Mesylate; Regitine Methanesulfonate; Regitipe; Rogitine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 19 minutes
Dosage Forms of Phentolamine Methanesulfonate: Solution Intravenous
Tablet, extended release Oral
Chemical IUPAC Name: 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol
Chemical Formula: C17H19N3O
Phentolamine on Wikipedia: https://en.wikipedia.org/wiki/Phentolamine
Organisms Affected: Humans and other mammals
